We know from history that genocide and related crimes against humanity do not just arise spontaneously. They often take place in the context of civil war, when leaders commit such crimes to advance their goals of eliminating opposition or perceived enemies. In the civil conflict now raging in Syria, reporting by independent journalists and the United Nations leaves little doubt that conditions are being laid for a dramatic escalation of violence against civilians, possibly based on their membership in religious sects. Right now the majority Sunni population, perceived by the Alawite-dominated regime to be leading the opposition, are the primary victims, but if conditions deteriorate, other groups—including Druze, Christians, and Alawites themselves—could also be targeted.